ABSTRACT
Objective: To compare the efficacy of felodipine versus propranolol in patients of essential hypertension for Serum cholesterol, LDL cholesterol and HDL cholesterol
Study Design: Randomized controlled study
Place and Duration of Study: This study was conducted at the Accident and Emergency Department, Bahawal Victoria Hospital, Bahawalpur and Ansari Private Clinic Model Town B Bahawalpur from 1[st] July 2015 to 30[th] September 2015
Materials and Methods: Total 90 patients with essential hypertension having age range from 30 to 50 years were enrolled in this study for three months. Patient were randomly divided into three groups I, II and III, each group comprising 30 patients. Group I patients were treated with felodipine, Group II patients were treated with propranolol and group III patients were treated with placebo. Effects of these drugs on Lipid profile [Serum cholesterol, HDL cholesterol and LDL cholesterol] were compared
Result: Felodipine, treated patients exhibited markedly significant fall in the serum cholesterol [P<0.01], highly significant fall at the level of LDL cholesterol [P<0.001] and non-significant effect in HDL cholesterol. Whereas propranolol treated patients showed highly significant increase of serum cholesterol [P<0.001], markedly significant increase in LDL cholesterol [P<0.01] and markedly significant decreased in HDL cholesterol [P<0.01]
Whereas comparison of two drugs Felodipine and Propranolol displayed a highly increased [P<0.001] serum cholesterol, LDL cholesterol and markedly increased [P<0.01] HDL cholesterol
Conclusion: Result of this study showing that comparing the two drugs felodipine had significantly decreased Serum cholesterol and LDL Cholesterol, whereas propranolol increased the Serum cholesterol, LDL cholesterol and decreased HDL cholesterol. So felodipine prove its merit over propranolol
ABSTRACT
Objective: To compare the efficacy of felodipine and propranolol in the treatment of essential hypertension
Study Design: Randomized controlled study
Place and Duration of Study: This study was conducted at Accident and Emergency Department,Bahawal VictoriaHospitalBahawalpurandAnsariPrivateClinicModelTownB,BahawalpurfromMarch2013toMay2013. Materials and Methods: Total 90 patients of mild to moderate essential hypertension both male and female between the ages of 30 to 55 years were enrolled to this study, for 90days patients were randomly divided intothree groups Group I, II and III. Efficiency of felodipine, propranolol and placebo tablets in the treatment essential hypertension wascompared
Results: Felodipine and propranolol both reduces the systolic blood pressure was highly significant [P<0.001] between day 0-15, day 0-30, day 0-45, day 0-60, day 0-75 and day 0-90. The placebo exhibited a non-significant effect on systolic blood pressure.In case of diastolic blood pressure patients treated with felodipine and propranolol the decrease of blood pressure was also significantly [P<0.001] for all time intervals. In placebo administered group the effect of diastolic blood pressure was non-significant at all-time intervals
Conclusion: Result of this study showing that both felodipine and propranolol significantly reduces blood pressure at all time of intervals. In addition felodipine has got an edge on propranolol that it is administered once daily
ABSTRACT
To study the effect of tribulus terristris on urinary pH, uric acid and calcium as a herbal diuretic agent. Descriptive study. The study was conducted postgraduate medical institute [PGMI] Lahore and duration of study was two weeks. Tribulus terristris extract [100 mg/kg body weight] was administered in rabbits. Rabbits are divided into two groups CT and Tt. There were significant alkalinization of urine and significant reduction in urinary uric acid level and insignificant urinary calcium level observed. It is concluded that alkalinization and reduction of urinary uric acid by Tt would be helpful to reduce renal stone formation
ABSTRACT
The objective of this study was to find the effects of herbal extract of tribulus terristris on the urine output and electrolytes in rabbits and to find a herbal remedy for fluid and electrolyte abnormalities. Descriptive. Department of Pharmacology and Therapeutics, Post Graduate Medical lnstitute, Lahore. The duration of study was for two weeks [in 2003]. Sixteen rabbits of mixed breed were purchased locally and kept in the animal house of Postgraduate Medical lnstitute, Lahore for a week for acclimatization before starting the experiment, Twelve hours light and dark cycle was maintained. They were fed on grass, grain, seasonal vegetables and water adlibitum. Animals were weighed for calculation of dosage of herb.
ABSTRACT
The volume of distribution and plasma concentration of alprazolam were assessed in fifteen hepatic insufficient patients. For this purpose, tab. Alprazolam 0.25 mg, orally was given twice a day, to five healthy, normal [control] subjects and fifteen hepatic insufficient patient. Drug was given for a period of twenty one days. Plasma concentration and Vd of alprazolam were evaluated on day seven and twenty one. Control group showed no change in plasma concentration and Vd on day 7 and 21. In hepatic group, there was a remarkable difference in plasma concentration on day 7 and 21, when compared with controls. In contrast, there was slight reduction in Vd in control vs hepatic group on day 21. So the study revealed that prolonged alprazolam treatment have less effect on Vd as compared to plasma concentration which was raised during long term therapy. Therefore, it is suggested that, the dose of alprazolm should be reduced in hepatic insufficient patients
Subject(s)
Humans , Male , Female , Liver Diseases , Alprazolam/pharmacokineticsABSTRACT
Alprazolam is a triazolobenzodiazepine which is primarily metabolized by the liver. To see its half life in hepatic insufficient patients tab. Alprazolam in a dose of 0.25 mg, B.D. was given orally to 15 such patients and 5 normal subjects taken as control. Drug was given for a period of 21 days to both groups. Blood samples were drawn at day 7 and 21. There was no remarkable change in half life on day 7 and 21, among control group. Same results were seen among hepatic group on both days but half life increased to about double on day 7 and 21, when compared to control ones. Thus, it was concluded that in hepatic insufficient patients, half life increases significantly due to alteration in hepatic biotransformation mechanism